? ??? ??? ????? ??? ????? ?? ?????? ?????? ?? ??? ???????? ?????? ??? ????? ?? ???? ???? ? ?? ???? ?? ??? ????? ??? ???? ????? ??? ? ??? ????? ? ????? ???GAZETTE: Ketamine has been around for a long time as anesthesia. What could you inform us about its use for depression?Tolerance is an important notion to consider into consideration with ketamine